Endocrine Abstracts

The antitumor properties of non-steroidal anti-inflammatory drugs (NSAIDs), with respect to both cancer prevention and therapy, have raised considerable interest in the last two decades, leading to well consolidated evidences in gastrointestinal cancers, especially colorectal cancer. NSAID action has been proposed to occur through two independent modes: a COX-dependent one, mainly involving the inhibition of COX-2-mediated PGE2 production, and a COX-independent one, mainly inv...